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RLX-33

Cat. No. M21591

All AbMole products are for research use only, cannot be used for human consumption.

RLX-33  Structure
Size Price Availability Quantity
5mg USD 300  USD300 In stock
10mg USD 480  USD480 In stock
25mg USD 620  USD620 In stock
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Quality Control & Documentation
Biological Activity

RLX-33 is a potent and selective blood-brain barrier permeable relaxin family peptide 3 (RXFP3) antagonist that also blocks relaxin 3 (Relaxin 3) -induced ERK1/2 phosphorylation. The IC50 phosphorylated RXFP3, ERK1 and ERK2 were 2.36μM, 7.82μM and 13.86μM, respectively. RLX-33 can block the increase of food intake in rats induced by RXFP3 selective agonist R3/I5. RLX-33 can be used in the study of metabolic syndrome.

Chemical Information
Molecular Weight 462.89
Formula C24H19ClN4O4
CAS Number 2784577-71-3
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Elaine A Gay, et al. J Med Chem. Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System

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Keywords: RLX-33 supplier, RXFP, inhibitors, activators

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