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RLX-33 is a potent and selective blood-brain barrier permeable relaxin family peptide 3 (RXFP3) antagonist that also blocks relaxin 3 (Relaxin 3) -induced ERK1/2 phosphorylation. The IC50 phosphorylated RXFP3, ERK1 and ERK2 were 2.36μM, 7.82μM and 13.86μM, respectively. RLX-33 can block the increase of food intake in rats induced by RXFP3 selective agonist R3/I5. RLX-33 can be used in the study of metabolic syndrome.
| Molecular Weight | 462.89 |
| Formula | C24H19ClN4O4 |
| CAS Number | 2784577-71-3 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related RXFP Products |
|---|
| CGEN-25010
CGEN-25010 is a relaxin receptor RXFP1/2 agonist that can be used in studies related to cardiovascular disease. |
| AZD3427
AZD-3427 is an RXFP1 agonist that may be used in studies related to cardiovascular disease. |
| Serelaxin
Serelaxin (RLX030) is a recombinant form of human relaxin-2 that attenuates cardiac fibrosis by inhibiting endothelial-to-mesenchymal transition through its action on endothelial relaxin family peptide receptor 1 (RXFP1), and may be used in studies related to heart failure. |
| AZD5462
AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties. |
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