RXFP Relaxin family peptide receptor

Cat.No.	Name	Information
M29828	AZD5462	AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties.
M21591	RLX-33	RLX-33 is a potent and selective blood-brain barrier permeable relaxin family peptide 3 (RXFP3) antagonist that also blocks relaxin 3 (Relaxin 3) -induced ERK1/2 phosphorylation. The IC50 phosphorylated RXFP3, ERK1 and ERK2 were 2.36μM, 7.82μM and 13.86μM, respectively. RLX-33 can block the increase of food intake in rats induced by RXFP3 selective agonist R3/I5. RLX-33 can be used in the study of metabolic syndrome.
M49392	CGEN-25010	CGEN-25010 is a relaxin receptor RXFP1/2 agonist that can be used in studies related to cardiovascular disease.
M31348	Serelaxin	Serelaxin (RLX030) is a recombinant form of human relaxin-2 that attenuates cardiac fibrosis by inhibiting endothelial-to-mesenchymal transition through its action on endothelial relaxin family peptide receptor 1 (RXFP1), and may be used in studies related to heart failure.