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Serelaxin

Cat. No. M31348

All AbMole products are for research use only, cannot be used for human consumption.

Serelaxin Structure
Synonym:

RLX030

Price and Availability

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Quality Control & Documentation
Biological Activity

Serelaxin (RLX030) is a recombinant form of human relaxin-2 that attenuates cardiac fibrosis by inhibiting endothelial-to-mesenchymal transition through its action on endothelial relaxin family peptide receptor 1 (RXFP1), and may be used in studies related to heart failure.

Chemical Information
Molecular Weight 5962.95
Formula C256H408N74O74S8
CAS Number 99489-94-8
Storage -20°C
References

[1] Tim Wilhelmi, et al. Theranostics. Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1

[2] Marco Metra, et al. N Engl J Med. Effects of Serelaxin in Patients with Acute Heart Failure

[3] Raktim Kumar Ghosh, et al. Cardiovasc Ther. Serelaxin in acute heart failure: Most recent update on clinical and preclinical evidence

[4] Maria Jelinic, et al. Microcirculation. Does serelaxin treatment alter passive mechanical wall properties in small resistance arteries?

[5] Jeremy Tietjens, et al. Heart. Serelaxin and acute heart failure

Related RXFP Products
CGEN-25010

CGEN-25010 is a relaxin receptor RXFP1/2 agonist that can be used in studies related to cardiovascular disease.

AZD3427

AZD-3427 is an RXFP1 agonist that may be used in studies related to cardiovascular disease.

AZD5462 

AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties.

RLX-33

RLX-33 is a potent and selective blood-brain barrier permeable relaxin family peptide 3 (RXFP3) antagonist that also blocks relaxin 3 (Relaxin 3) -induced ERK1/2 phosphorylation. The IC50 phosphorylated RXFP3, ERK1 and ERK2 were 2.36μM, 7.82μM and 13.86μM, respectively. RLX-33 can block the increase of food intake in rats induced by RXFP3 selective agonist R3/I5. RLX-33 can be used in the study of metabolic syndrome.

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Keywords: Serelaxin, RLX030 supplier, RXFP, inhibitors, activators

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