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CYH33 methanesulfonate is an orally active, highly selective PI3Kα inhibitor with IC50s of 5.9 nM/598 nM/78.7 nM/225 nM against α/β/δ/γ isoform, respectively. CYH33 methanesulfonate inhibits phosphorylation of Akt, ERK and induces significant G1 phase arrest in breast cancer cells and non-small cell lung cancer (NSCLC) cells. CYH33 methanesulfonate has potent activity against solid tumors.
| Molecular Weight | 694.7 |
| Formula | C25H33F3N8O8S2 |
| CAS Number | 1494684-33-1 |
| Form | Solid |
| Storage | 4°C, dry, sealed |
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