About 6 results found for searched term "R-406" (0.056 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1767 | R-406 | Syk |
| R406 free base | ||
| R406 is an orally bioavailable and selective inhibitor of spleen tyrosine kinase (Syk) with the IC50 of 41nM and Ki value of 30 nM. | ||
| M7534 | SSR240612 | Bradykinin Receptor |
| Treatment with the kinin B1 receptor antagonist, SSR240612, provided a protective effect against organ damage by interfering with multiple target functions, including the suppression of B1R-induced inflammation and platelet aggregation. | ||
| M9924 | Risdiplam | DNA/RNA Synthesis |
| RG7916; RO7034067 | ||
| Risdiplam (also known as RG7916 and RO7034067) is a gene splicing modulator (neuromuscular disease) that distributes into the central nervous system (CNS) and peripheral tissues. | ||
| M13549 | Xevinapant hydrochloride | IAP |
| AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride | ||
| Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). | ||
| M14916 | R406 besylate | Syk |
| R406 benzenesulfonate; Tamatinib | ||
| R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. | ||
| M24877 | Cobolimab | Others |
| TSR-022; GSK4069889 | ||
| Cobolimab (TSR-022) is an anti-TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC50 value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC). | ||
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