About 7 results found for searched term "Protein Synthesis IN-1" (0.417 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4879 | Protein Synthesis IN-1 | DNA/RNA Synthesis |
| Protein Synthesis IN-1 (a substitute for Cycloheximide) is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. Protein Synthesis IN-1 binds to the E-site of the 60S subunit of the ribosome during the protein synthesis process in eukaryotic cells, blocking the ribosome translocation process mediated by eEF2 and preventing the synthesis of new proteins. Protein Synthesis IN-1 suppresses ferroptosis and inhibits autophagy. | ||
| M2914 | Paromomycin Sulfate | Antibiotic |
| Aminosidine sulfate; Paromomycin sulfate salt | ||
| Paromomycin Sulfate is an aminoglycoside antibioticis inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA. | ||
| M15020 | Recombinant Rat CNTF (E. coli) | Cytokines and Growth Factors |
| Ciliary Neurotrophic Factor | ||
| Recombinant rat CNTF protein (E. coli) is a peptide hormone that acts on the nervous system and promotes neurotransmitter synthesis and neurite growth in certain neuron populations. Protein structure: CNTF (ALA2-MET200), Accession # P20294-1. | ||
| M20800 | ASLAN003 | DHODH |
| LAS 186323; Farudodstat | ||
ASLAN003 (LAS 186323) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors. |
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| M28263 | Quiflapon | Lipoxygenase |
| MK-591 | ||
| Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC50 values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis. | ||
| M39215 | Eurycomalactone | NF-κB |
| Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. | ||
| M4881 | RNA Synthesis IN-1 | DNA/RNA Synthesis |
| RNA Synthesis IN-1 (a substitute for Actinomycin D) is an inhibitor of RNA and protein synthesis, with antibacterial and anti-tumor effects. RNA Synthesis IN-1 can inhibit the protein synthesis of bacteria, directly bind to the guanine groups of single-stranded or double-stranded DNA in the transcriptional initiation complex, inhibit the activity of DNA-dependent RNA polymerase, and interfere with the transcription process of DNA, thereby inhibiting mRNA synthesis. RNA Synthesis IN-1 inhibits DNA repair with an IC50 value of 0.42 μM. | ||
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