About 9 results found for searched term "PY-60" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5366 | 4-Aminoantipyrine | COX |
| Ampyrone, NSC 60242 | ||
| 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. | ||
| M20901 | Piperonyl butoxide | Others |
| Butacide, Ethanol butoxide, Pyrenone 606 | ||
| Piperonyl butoxide (PBO) is a man-made pesticide synergist, working with insect killers to increase their effectiveness. | ||
| M21083 | PY-60 | YAP |
| PY-60 is a specific activator (Kd=1.4 µM) of YAP transcriptional activity targeting membrane associated protein A2 (ANXA2).PY-60 binds directly to ANXA2 and antagonizes its normal cellular function of inhibiting YAP activity. | ||
| M29770 | Spiclomazine hydrochloride | Ras |
| APY-606; Clospirazine hydrochloride | ||
| Spiclomazine hydrochloride (APY-606) is an antipsychotic and antitumor agent. Spiclomazine hydrochloride inhibits KRas. Spiclomazine hydrochloride induces cancer cell apoptosis. | ||
| M2870 | MSDC-0160 | Others |
| Mitoglitazone; CAY10415 | ||
| MSDC 0160 (Mitoglitazone) is an insulin sensitizer that regulates the mitochondrial target of thiazolidinedione (mTOT) and a regulator of mitochondrial pyruvate vector (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has potential for use in Alzheimer's disease. | ||
| M3243 | Pyroxamide | HDAC |
| NSC-696085 | ||
| Pyroxamide (NSC 696085) is a potent, affinity-purified HDAC1 inhibitor with ID50 of 100 nM. | ||
| M5043 | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | Others |
| 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate, which is widely used in the synthesis of many pharmaceutical intermediates at home and abroad. Including CP690550, CGP76030 and so on, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the scaffold for many commercially available drugs. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response. | ||
| M8622 | TVB-3166 | FAS |
| TVB3166 | ||
| TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p. | ||
| M8723 | PBOX-15 | Others |
| PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). | ||
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