About 6 results found for searched term "PX 12" (0.273 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7929 | PX 12 | HIF |
| IV-2; PX12 | ||
| Px-12 (IV-2) is a reversible thioredoxin 1 (TRX-1) inhibitor. | ||
| M29194 | Fosmanogepix | Antifungal |
| APX001; E1211 | ||
| Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl precursor which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections. | ||
| M29269 | PXS-5120A | Monoamine Oxidase |
| PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 (Ki of 83 nM; pIC50 of 8.4) over LOXL (pIC50 of 5.8). | ||
| M6186 | Repotrectinib (TPX-0005) | ALK |
| TPX-0005; Repotrectinib | ||
| Repotrectinib (TPX-0005) is a potential best-in-class ALK/ROS1/TRK inhibitor against SRC, wild-type WT ALK, The IC50 values of ALK G1202R and ALK L1196M were 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM, respectively. | ||
| M29473 | Elzovantinib | Src-bcr-Abl |
| TPX-0022; CSF1R-IN-2 | ||
| Elzovantinib (TPX-0022) is an oral-active inhibitor of SRC, MET and c-FMS, with IC50 values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively. | ||
| M42429 | GPX4-IN-5 | Glutathione Peroxidase |
| GPX4-IN-5 is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM. | ||
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