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Fosmanogepix

Cat. No. M29194

All AbMole products are for research use only, cannot be used for human consumption.

Fosmanogepix Structure
Synonym:

APX001; E1211

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Quality Control & Documentation
Biological Activity

Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl precursor which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections.

Chemical Information
Molecular Weight 468.4
Formula C22H21N4O6P
CAS Number 2091769-17-2
Form Solid
Solubility (25°C) DMSO 5 mg/mL (ultrasonic and adjust pH to 4 with HCl)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Drew J Winston, et al. Clin Infect Dis. Fosmanogepix Therapy of Disseminated Fusarium Infection

[2] Samantha E Jacobs, et al. F1000Res. Novel antifungal agents in clinical trials

[3] Martin Hoenigl, et al. Drugs. The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin

[4] Karen Joy Shaw, et al. J Fungi (Basel). Fosmanogepix: A Review of the First-in-Class Broad Spectrum Agent for the Treatment of Invasive Fungal Infections

[5] Teclegiorgis Gebremariam, et al. Antimicrob Agents Chemother. Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus

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Keywords: Fosmanogepix, APX001; E1211 supplier, Antifungal, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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