About 10 results found for searched term "PPO-IN-2" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43036 | PPO-IN-2 | Others |
| PPO-IN-2 is an inhibitor of protoporphyrinogen IX oxidase with an Ki of 16 nM. | ||
| M9057 | XMU-MP-1 | Hippo (MST) |
| XMU-MP-1 is a potent and selective Hippo/ MST1/2 inhibitor with IC50 values of 71.1 ± 12.9 nM and 38.1 ± 6.9 nM, respectively. | ||
| M10022 | Recombinant Mouse GM-CSF Protein (CHO) | Cytokines and Growth Factors |
| CSF-2 | ||
| Recombinant GM-CSF Protein is a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. GM-CSF is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory. ED50 < 0.05 ng/ml, measured in a cell proliferation assay using mouse FDC-P1 cells, corresponding to a specific activity of > 2.0 × 107 units/mg. | ||
| M11485 | Recombinant Mouse GM-CSF Protein (E. coli) | Cytokines and Growth Factors |
| Granulocyte Macrophage Colony Stimulating Factor; CSF-2; MGI-1GM | ||
| Recombinant GM-CSF Protein is a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. GM-CSF is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory. ED50 < 5.0 pg/ mL, measured in cell proliferation assay of mouse FDC-P1 cells, corresponding specific activity > 2.0 × 108 units/mg. | ||
| M27803 | Leucettine L41 | CDK |
| Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 µM, respectively). Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Aβ25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Aβ25-35 in the same model. | ||
| M28442 | β-Amyloid (22-35) | Amyloid |
| Amyloid β-Protein (22-35) | ||
| β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution). | ||
| M29014 | WRG-28 | Discoidin Domain Receptor |
| WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice. | ||
| M29222 | Yhhu-3792 | Notch |
| Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction. | ||
| M29711 | CMLD010509 | c-Myc |
| SDS-1-021 | ||
| CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism. | ||
| M49483 | B-355252 | Apoptosis |
| B-355252 is a phenoxythiophene sulfonamide small molecule and a potent NGF receptor agonist that enhances NGF-induced neurite growth. It also protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and LDH levels, and preventing neuronal apoptosis. In addition, B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity and in a mouse hippocampal cell line (HT22) model of Parkinson's disease (PD). | ||
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