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Recombinant Mouse GM-CSF Protein (CHO)

Cat. No. M10022
Recombinant Mouse GM-CSF Protein (CHO) Structure
Synonym:

CSF-2

Size Price Availability Quantity
10ug USD 200  USD200 In stock
50ug USD 625  USD625 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant GM-CSF Protein is a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. GM-CSF is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory stimuli. Additionally, Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) can stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma, and adenocarcinoma cell lines.

ED50 < 0.05 ng/ml, measured in a cell proliferation assay using mouse FDC-P1 cells, corresponding to a specific activity of > 2.0 × 107 units/mg.


Accession: # Q14AD9

Apparent Molecular Weight: 15~19 kDa, on SDS-PAGE under non-reducing conditions.

Lyophilized after extensive dialysis against PBS.

Product Citations
Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml
Storage Stable for up to 6 months at lower than -70°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Mouse GM-CSF Protein (CHO), CSF-2 supplier, Recombinant Proteins, inhibitors, activators


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