About 4 results found for searched term "Nrf2 activator-7" (0.139 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42730 | Nrf2 activator-7 | Keap1-Nrf2 |
| Nrf2 activator-7 is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway. | ||
| M29455 | DDO-7263 | Keap1-Nrf2 |
| DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD). | ||
| M31251 | CBR-470-1 | Keap1-Nrf2 |
| CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade. | ||
| M42734 | Nrf2 activator-8 | Keap1-Nrf2 |
| Nrf2 activator-8 is a Nrf2 activator (EC50=37.9 nM). | ||
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