Nrf2 activator-3 - Search Results

About 5 results found for searched term "Nrf2 activator-3" (0.124 seconds)

Cat.No.	Name	Target
M42736	Nrf2 activator-3	Keap1-Nrf2
	Nrf2 activator-3 is a potent Nrf2 activator.
M7182	RA 839	Keap1-Nrf2
	RA839
	RA 839 is a nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). RA 839 suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.
M8767	MIND4-17	Others
	MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2.
M29455	DDO-7263	Keap1-Nrf2
	DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD).
M42734	Nrf2 activator-8	Keap1-Nrf2
	Nrf2 activator-8 is a Nrf2 activator (EC50=37.9 nM).