Mercaptopurine - Search Results

About 4 results found for searched term "Mercaptopurine" (0.121 seconds)

Cat.No.	Name	Target
M3258	Thioguanine	DNA/RNA Synthesis
	6-Thioguanine; 6-TG; 2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol
	Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.
M5375	6-Mercaptopurine (6-MP) Monohydrate	DNA/RNA Synthesis
	6-MP
	Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting phosphoribose pyrophosphate amide transferase (PRPP amide transferase). PRPP amide transferase is a rate-limiting enzyme formed by purine. It alters the synthesis and function of RNA and DNA. Mercaptopurine also interferes with nucleoside tautomies and glycoprotein synthesis.
M5771	Mercaptopurine	DNA/RNA Synthesis
	6-MP
	Mercaptopurine (6-MP) inhibits neopurine synthesis by incorporating methyltransferase metabolites of Mercaptopurine into DNA and RNA.
M30644	PU 23	Others
	PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine.