About 9 results found for searched term "MEK-IN-6" (0.126 seconds)
Cat.No. | Name | Target |
---|---|---|
M1744 | ARRY-162 (Binimetinib) | MEK |
MEK-162; Binimetinib; ARRY-438162 | ||
ARRY-162 (MEK-162; Binimetinib) is a selective, potent inhibitor of MEK and cellular pERK with IC50 of 12 nM and 11 nM, respectively. | ||
M42145 | MEK-IN-6 hydrate | MEK |
MEK-IN-6 hydrate is a MEK inhibitor. | ||
M43554 | MEK-IN-6 | ERK |
MEK-IN-6 is a MEK inhibitor. | ||
M1763 | Mirdametinib (PD0325901) | MEK |
Mirdametinib;PD325901 | ||
Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM. | ||
M10369 | RO5126766 (VS-6766) | MEK |
CH5126766; VS 6766; Avutometinib | ||
RO5126766 (CH5126766, VS 6766) is a first-in-class dual MEK/RAF inhibitor with IC50 values of 8.2 nM, 19 nM, 56 nM and 160 nM for BRAF V600E, BRAF, CRAF and MEK1, respectively. | ||
M14169 | GDC-0623 | MEK |
RG 7421; MEK inhibitor 1 | ||
GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM). | ||
M14171 | Selumetinib sulfate | MEK |
AZD6244 sulfate; ARRY-142886 sulfate | ||
Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. | ||
M27786 | U0126 | MEK |
U0126 is a potent, non-ATP-competitive, selective inhibitor of MEK1 and MEK2 with IC50s of 72 nM and 58 nM, respectively.In addition, U0126 is an autophagy and mitophagy inhibitor and inhibits LPA-induced entosis. | ||
M30350 | E6201 | MEK |
ER-806201 | ||
E6201 (ER-806201) is an ATP-competitive dual kinase inhibitor of MEK1 and FLT3. E6201 inhibits MEK1- induced ERK2 phosphorylation with an IC50 value of 5.2 nM, MKK4-induced JNK phosphorylation with an IC50 value of 91 nM, and MKK6-induced p38 MAPK phosphorylation with an IC50 value of 19 nM. Anti-tumor and anti-psoriasis efficacy. |
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