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E6201

Cat. No. M30350

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E6201 Structure
Synonym:

ER-806201

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Quality Control & Documentation
Biological Activity

E6201 (ER-806201) is an ATP-competitive dual kinase inhibitor of MEK1 and FLT3. E6201 inhibits MEK1- induced ERK2 phosphorylation with an IC50 value of 5.2 nM, MKK4-induced JNK phosphorylation with an IC50 value of 91 nM, and MKK6-induced p38 MAPK phosphorylation with an IC50 value of 19 nM. Anti-tumor and anti-psoriasis efficacy.

Chemical Information
Molecular Weight 389.44
Formula C21H27NO6
CAS Number 603987-35-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Jangsoon Lee, et al. Breast Cancer Res Treat. Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer

[2] Hani M Babiker, et al. Invest New Drugs. E6201, an intravenous MEK1 inhibitor, achieves an exceptional response in BRAF V600E-mutated metastatic malignant melanoma with brain metastases

[3] Gautham Gampa, et al. Drug Metab Dispos. Brain Distribution of a Novel MEK Inhibitor E6201: Implications in the Treatment of Melanoma Brain Metastases

[4] Kenzo Muramoto, et al. J Pharmacol Exp Ther. E6201, a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-1 and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase-1: in vivo effects on cutaneous inflammatory respon䲧癐Ỵ癑㧀癏羹瘸盋晸Ƙ

[5] Masaki Goto, et al. J Pharmacol Exp Ther. E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-1 䲧癐Ỵ癑㧀癏羹瘸盋晸ƘƌƘÐ�瘺嶁瘶Ѐ瑖抩䀹⹜ࢹƘÐèࢹ彿抪奋抪巫抪䬄ࢹ嫼ࢹ彿抪嫰ࢹ塚抪嫼

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Keywords: E6201, ER-806201 supplier, MEK, inhibitors, activators

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