About 30 results found for searched term "LC-2" (0.046 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1686 | Bortezomib (PS-341) | Proteasome |
| Velcade; PS-341; LDP 341; MG 341; NSC 681239 | ||
| Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. | ||
| M2107 | Calcium levofolinate | Others |
| Levoleucovorin Calcium; CL307782 | ||
| Calcium levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. | ||
| M4968 | Mitiglinide calcium hydrate | Potassium Channel |
| KAD-1229 calcium hydrate; S-21403 calcium hydrate | ||
| Miglinide calcium hydrate is a compound used to study type 2 diabetes mellitus. It is a highly selective KATP channel antagonist. | ||
| M5736 | Levocarnitine propionate | Others |
| L-Propionylcarnitine chloride; ST-261 | ||
| Levocarnitine propionate hydrochloride is used for the study of renal function deterioration, congestive heart failure, intermittent claudication and other diseases. | ||
| M6026 | Tranylcypromine (2-PCPA) HCl | Monoamine Oxidase |
| SKF-385 HCl; Trans 2-Phenylcyclopropylamine Hydrochloride | ||
| Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively. Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. | ||
| M9712 | Pyrocatechuic acid | Metabolite/Endogenous Metabolite |
| 2,3-Dihydroxybenzoic acid; Catecholcarboxylic acid; NSC 27435 | ||
| Pyrocatechuic acid (2,3-Dihydroxybenzoic acid) is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion. | ||
| M10385 | LC-2 | PROTAC |
| LC-2 is a potent first-in-class PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM. | ||
| M20436 | Calcium dobesilate | Others |
| calcium dihydroxy-2,5-benzenesulfonate | ||
| Calcium dobesilate is a vascular protector with oral activity that can clear hydroxyl free radicals, with an IC50 of 1.1 pM. Calcium dobesilate has antioxidant activity and helps to reduce oxidative stress and inflammation in the retinas of diabetic mice. | ||
| M20498 | Ethyl (triphenylphosphoranylidene) acetate | AChR/AChE |
| (Carbethoxymethylene)triphenylphosphorane, Triphenylcarbethoxymethylenephosphorane, Ethyl 2-(triphenylphosphoranylidene)acetate | ||
| Ethyl (triphenylphosphoranylidene) acetate may act as an inhibitor of cholinesterase that inhibits AChE and BChE. | ||
| M21070 | Glucosylceramide synthase-IN-2 | Glucosylceramide Synthase |
| T-690 | ||
| Glucosylceramide-IN-2 (T-690) is a potent, blood-brain barrier-transparent and orally active inhibitor of glucosylceramide synthase (GCS) with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively. basal and non-competitive with UDP-glucose. | ||
| M21201 | Recombinant Mouse Lipocalin-2/NGAL Protein (HEK293, C-6His) | Cytokines and Growth Factors |
| Neutrophil gelatinase-associated lipocalin; LCN2 | ||
| Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 can tightly bind to bacterial siderophore through a cell surface receptor, possibly serving as a potent bacteriostatic agent by sequestering iron, regulating innate immunity and protecting kidney epithelial cells from ischemia–reperfusion injury. | ||
| M21202 | Recombinant Human Lipocalin-2/NGAL/LCN2 (E. coli, C-6His) | Cytokines and Growth Factors |
| Neutrophil gelatinase-associated lipocalin; NGAL | ||
| Human neutrophil gelatinase-associated lipid transport protein (Lipocalin-2/NGAL/LCN2) is produced by the E. coli expression system and the target gene encoding Gln21-Gly198 has a 6His tag at the C-terminus.Protein number: P80188 | ||
| M25384 | Recombinant Human KEAP1 Protein (Baculovirus-Insect, His & GST Tag) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | ||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | ||
| M25383 | Recombinant Human KEAP1 Protein (Baculovirus-Insect) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | ||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | ||
| M25434 | Tranylcypromine (2-PCPA) HCl (≥97.0%) | Monoamine Oxidase |
| SKF-385 HCl; Trans 2-Phenylcyclopropylamine Hydrochloride | ||
| Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively. Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. | ||
| M28227 | Vidofludimus hemicalcium | DHODH |
| 4sc-101 hemicalcium; SC12267 hemicalcium | ||
| Vidofludimus (4sc-101; SC12267) hemicalcium is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR). Vidofludimus hemicalcium, as an immunomodulatory agent, can be used for the research of autoimmune disorders such as inflammatory bowel disease (IBD). Vidofludimus hemicalcium also can be used for the research of fatty liver by targeting FXR. | ||
| M58156 | Recombinant Human PRDX6 Protein (E. coli, N-6His) | Cytokines and Growth Factors |
| Peroxiredoxin-6; 1-Cys Peroxiredoxin; Acidic Calcium-Independent Phospholipase A2 | ||
| Peroxiredoxin 6 (PRDX6) belongs to the thiol-specific antioxidant protein family, it is involved in redox regulation of the cell and can reduce Hydrogen peroxide and short chain organic, fatty acid, and phospholipid hydroperoxides. Peroxiredoxin 6 may regulates phospholipid turnover and protectes against oxidative injury. | ||
| M30952 | Lck inhibitor 2 | Src-bcr-Abl |
| Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively IC50 Value: 13 nM(Lck) [1] Target: Src family kinase Lck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM). | ||
| M39080 | Lysophosphatidylcholine 18:2 | Metabolite/Endogenous Metabolite |
| Lysophosphatidylcholine 18:2 (1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC), a lysophospholipid, is a potential biomarker identified from insulin resistance (IR) polycystic ovary syndrome (PCOS). | ||
| M39983 | Pulchinenoside E2 | Others |
| Pulchinenoside E2 (Compound 8) is a triterpene saponin isolated from the roots of Pulsatilla chinensis. Pulchinenoside E2 shows cytotoxic to HL-60 cells with an IC50 value of 2.6 µg/mL. | ||
| M42193 | SLC26A3-IN-2 | GLUT |
| SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). | ||
| M42194 | SLC26A3-IN-1 | GLUT |
| SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). | ||
| M42196 | SLC26A3-IN-3 | GLUT |
| SLC26A3-IN-3 is a SLC26A3 inhibitor (IC50: 40 nM). | ||
| M42475 | ALC-0315 analogue-2 | Liposome |
| ALC-0315 analogue-2 is an analogue of ALC-0315. | ||
| M43500 | LC-MB12 | FGFR |
| LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. | ||
| M51402 | KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 | Others |
| KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 is a polypeptide that can be found by peptide screening. | ||
| M52302 | Ethyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate | Amino Acid Derivatives |
| Ethyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate is an alanine derivative. | ||
| M52594 | Antiulcer Agent 2 | Metabolite/Endogenous Metabolite |
| Antiulcer Agent 2 is a tetrapeptide containing aspartic acid, alanine, histidine, and lysine. | ||
| M53227 | [Tyr22] Calcitonin Gene Related Peptide, (22-37), rat | CGRP Receptor |
| [Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and adenylate cyclase. | ||
| M53920 | Calcitonin (8-32), salmon | Others |
| Calcitonin (8-32), salmon is a highly selective amylin receptor antagonist. | ||
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