About 9 results found for searched term "Kushenol W" (0.118 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M38695 | Kushenol W | Antibiotic |
| Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus. | ||
| M16672 | Sophoraflavanone G | Apoptosis |
| Kushenol F | ||
| Sophoraflavanone G induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways. Sophoraflavanone G (Kushenol F) shows anti-tumor and anti-inflammatory properties. | ||
| M18469 | Flemiphilippinin D | IDO |
| Kushenol E | ||
| Flemiphilippinin D (Kushenol E) is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM. Flemiphilippinin D (Kushenol E) is a flavonoid isolated from Sophora flavescens, it has anti-tumor activity. | ||
| M19233 | Kushenol A | Tyrosinase |
| Leachianone E | ||
| Kushenol A (Leachianone E) is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively. | ||
| M27633 | Kushenol K | Cytochrome P450 (e.g. CYP17) |
| K | ||
| Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM). Kushenol K also inhibits the activity of SGLT1 and SGLT2. | ||
| M39062 | Kushenol M | Cytochrome P450 (e.g. CYP17) |
| Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC50 values of 1.29 μM for CYP3A4 in human liver microsomes. | ||
| M39172 | Kushenol B | PDE |
| Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities. Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC50 of 31 µM. | ||
| M39189 | Kushenol C | BACE |
| Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM. | ||
| M40102 | Kushenol X | Others |
| Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively. | ||
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