About 5 results found for searched term "JAK3-IN-11" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M49592 | JAK3-IN-11 | JAK |
| JAK3-IN-11 , a potent, noncytotoxic, irreversible, orally active JAK3 inhibitor with IC50 value of 1.7 nM, has excellent selectivity (>588-fold compared to other JAK isoforms), covalently bind to the ATP-binding pocket in JAK3. | ||
| M10417 | Delphinidin chloride | JAK |
| delfinidolchloride | ||
| Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which can modulate JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells. | ||
| M49586 | JAK3 covalent inhibitor-1 | JAK |
| JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs. | ||
| M49594 | JAK3-IN-7 | JAK |
| JAK3-IN-7 is a potent and selective JAK3 inhibitor extracted from patent WO2011013785A1, has an IC50 of <0.01 μM. | ||
| M49776 | SJ10542 | PROTAC |
| SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. | ||
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