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Delphinidin chloride

Cat. No. M10417
Delphinidin chloride Structure
Synonym:

delfinidolchloride

Size Price Availability Quantity
5mg USD 230  USD230 In stock
10mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which can modulate JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells. Delphinidin chloride shows endothelium-dependent vasorelaxation. It also inhibits signaling through epithelial growth factor receptors, suppressing the expression of estrogen receptor α and inducing both apoptosis and autophagy at a dose of 1-40 μM.

Chemical Information
Molecular Weight 338.7
Formula C15H11ClO7
CAS Number 528-53-0
Solubility (25°C) DMSO 50 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anshul Sharma, et al. Int J Mol Sci. Delphinidin and Its Glycosides' War on Cancer: Preclinical Perspectives

[2] Zhixi Chen, et al. J Agric Food Chem. The Multifunctional Benefits of Naturally Occurring Delphinidin and Its Glycosides

[3] Bin Han, et al. Cancer Sci. Delphinidin suppresses breast carcinogenesis through the HOTAIR/microRNA-34a axis

[4] Abu Hazafa, et al. Nutr Cancer. The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

[5] Ki Hyeob Hyun, et al. J Food Sci. Delphinidin Chloride and Its Hydrolytic Metabolite Gallic Acid Promote Differentiation of Regulatory T cells and Have an Anti-inflammatory Effect on the Allograft Model

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