About 27 results found for searched term "IRAK4-IN-4" (0.138 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14092 | IRAK4-IN-4 | IRAK |
| IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 of 2.8 nM. | ||
| M41999 | IRAK4-IN-24 | IRAK |
| IRAK4-IN-24 is a potent IRAK4 inhibitor, with high clearance (Cl) and poor oral bioavailability. | ||
| M9340 | IRAK-1-4 Inhibitor I | IRAK |
| IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.3 μM and 0.2 μM, respectively. | ||
| M9834 | E3 ligase Ligand 4 | Ligand for E3 Ligase |
| Thalidomide 4-fluoride | ||
| E3 ligase Ligand 4 (Thalidomide 4-fluoride) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it can connect to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. | ||
| M10198 | Zabedosertib | IRAK |
| BAY1834845 | ||
| Zabedosertib (BAY 1834845) is a selective, orally potent IRAK4 inhibitor with immunomodulatory and anti-inflammatory activity and an IC50 value of 3.55 nM. Zabedosertib (BAY 1834845) exhibits anti-inflammatory property against IL-β, LPS and Imiquimod induced inflammation. | ||
| M14094 | IRAK inhibitor 4 | IRAK |
| IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor. | ||
| M20807 | IRAK4-IN-1 | IRAK |
| Compound 23 | ||
| IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM. | ||
| M21388 | IRAK4-IN-20 | IRAK |
| IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 may be used in studies of acute respiratory distress syndrome (ARDS). | ||
| M21784 | AZ1495 | IRAK |
| AZ1495 is a weak base and orally active, potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with a Kd value of 0.0007 μM.AZ1495 has good physicochemical and kinase selectivity for IRAK4 and IRAK1, with IC50 values of 0.005 μM and 0.023 μM, respectively.AZ1495 is used in studies of diffuse large B-cell lymphoma (DLBCL). | ||
| M29213 | GLPG2534 | IRAK |
| GLPG2534 is an orally active and selective IRAK4 inhibitor, with IC50 values of 6.4 nM and 3.5 nM for human and mouse IRAK4. GLPG2534 can be used for the research of inflammatory skin diseases. | ||
| M29236 | GNE-2256 | IRAK |
| GNE-2256 (molecule 19) is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM; IL-6 IC50=190 nM). | ||
| M29370 | HG-12-6 | IRAK |
| HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation. | ||
| M29530 | PROTAC IRAK4 degrader-1 | PROTAC |
| PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively. | ||
| M29635 | PROTAC IRAK4 degrader-7 | PROTAC |
| KT-474; SAR444656 | ||
| PROTAC IRAK4 degrader-7 (Compound I-417) is a potentially first-in-class, orally active PROTAC IRAK4 degrader with antitumor activity for studies related to hidradenitis suppurativa (HS) and atopic dermatitis (AD). | ||
| M29657 | IRAK4-IN-6 | IRAK |
| IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma. | ||
| M54868 | BIO-7488 | IRAK |
| BIO7488 | ||
| BIO-7488 is a potent, selective, oral active and CNS-penetrant IRAK4 inhibitor, with IC50 values of 0.6 nM and >30 μM for IRAK4 and hERG, respectively. | ||
| M41998 | IRAK4-IN-25 | IRAK |
| IRAK4-IN-25 is an orally acitve and potent IRAK4 inhibitor (IC50=7.3 nM), with low clearance (Cl=12 mL/min/kg). | ||
| M42000 | IRAK4-IN-27 | IRAK |
| IRAK4-IN-27 is a potent, selective inhibitor of IRAK4, with IC50 of 8.7 nM. | ||
| M42001 | PROTAC IRAK4 degrader-8 | IRAK |
| PROTAC IRAK4 degrader-8 is a PROTAC targeting to IRAK4 (IC50=15.5 nM). | ||
| M42002 | IRAK4-IN-28 | IRAK |
| IRAK4-IN-28 is an orally active IRAK4 inhibitor (IC50=8.9 nM). | ||
| M42004 | IRAK4-IN-26 | IRAK |
| IRAK4-IN-26 is a IRAK4 inhibitor (IC50: 6.2 nM). | ||
| M54681 | IRAK4-IN-21 | IRAK |
| IRAK4-IN-21 is an orally potent, selective, and potent IRAK4 inhibitor with IC50 values of 5 and 56 nM for IRAK4 and TAK1, respectively.IRAK4-IN-21 potently inhibits the production of IL-23 (IC50=0.17 µM) and may be useful in studies related to autoimmune diseases such as plaque psoriasis and psoriasis vulgaris. arthritis). | ||
| M54683 | PROTAC IRAK4 degrader-3 | IRAK |
| PROTAC IRAK4 degrader-3 is a von Hippel-Lindau based IRAK4 degrader PROTAC. | ||
| M54679 | IRAK-4 protein kinase inhibitor 2 | IRAK |
| IRAK-4 protein kinase inhibitor 2 is a potent interleukin 1 (IL-1) receptor-associated kinase 4 (IRAK-4) inhibitor with an IC50 value of 4 μM.IRAK-4 protein kinase inhibitor 2 can be used in the study of inflammatory and immune-related diseases. | ||
| M54685 | IRAK4-IN-22 | IRAK |
| IRAK4-IN-22 is an orally potent and selective potent IRAK4 inhibitor with IC50 values of 3 and 17 nM for IRAK4 and TAK1, respectively.In addition, IRAK4-IN-21 potently inhibits the production of IL-23 (IC50=0.10 µM), which may be useful in studies related to autoimmune diseases such as plaque psoriasis and psoriasis vulgaris. arthritis). | ||
| M54682 | IRAK inhibitor 4 (trans) | IRAK |
| IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4 and a potent inhibitor of IRAK4. | ||
| M56368 | HS-243 | IRAK |
| HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC50 values of 20 and 24 nM. | ||
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