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GNE-2256 

Cat. No. M29236

All AbMole products are for research use only, cannot be used for human consumption.

GNE-2256  Structure

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Quality Control & Documentation
Biological Activity

GNE-2256 (molecule 19) is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM; IL-6 IC50=190 nM).

Chemical Information
Molecular Weight 482.51
Formula C24H27FN6O4
CAS Number 2102170-43-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Related IRAK Products
HS-243 

HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC50 values of 20 and 24 nM.

BIO-7488

BIO-7488 is a potent, selective, oral active and CNS-penetrant IRAK4 inhibitor, with IC50 values of 0.6 nM and >30 μM for IRAK4 and hERG, respectively.

IRAK4-IN-22

IRAK4-IN-22 is an orally potent and selective potent IRAK4 inhibitor with IC50 values of 3 and 17 nM for IRAK4 and TAK1, respectively.In addition, IRAK4-IN-21 potently inhibits the production of IL-23 (IC50=0.10 µM), which may be useful in studies related to autoimmune diseases such as plaque psoriasis and psoriasis vulgaris. arthritis).

HS271

HS271 is an orally potent and selective IRAK4 inhibitor with an IC50 value of 7.2 μM. In addition, HS271 has superior in vitro enzymatic and cellular activities.

PROTAC IRAK4 degrader-3

PROTAC IRAK4 degrader-3 is a von Hippel-Lindau based IRAK4 degrader PROTAC.

  Catalog
Abmole Inhibitor Catalog




Keywords: GNE-2256  supplier, IRAK, inhibitors, activators

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