| Cat.No. | Name | Information |
|---|---|---|
| M54679 | IRAK-4 protein kinase inhibitor 2 | IRAK-4 protein kinase inhibitor 2 is a potent interleukin 1 (IL-1) receptor-associated kinase 4 (IRAK-4) inhibitor with an IC50 value of 4 μM.IRAK-4 protein kinase inhibitor 2 can be used in the study of inflammatory and immune-related diseases. |
| M29821 | HS-276 | HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research. |
| M21039 | JH-X-119-01 | JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK1 with IC50 of 9 nM. |
| M20807 | IRAK4-IN-1 | IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with IC50 of 7 nM. |
| M20680 | IRAK inhibitor 6 | IRAK inhibitor 6 is a selective Interleukin-1 receptor-associated kinase 4(IRAK4) inhibitor with IC50 of 0.16 μM. |
| M14092 | IRAK4-IN-4 | IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 of 2.8 nM. |
| M10198 | Zabedosertib | Zabedosertib (BAY 1834845) is a selective, orally potent IRAK4 inhibitor with immunomodulatory and anti-inflammatory activity and an IC50 value of 3.55 nM. Zabedosertib (BAY 1834845) exhibits anti-inflammatory property against IL-β, LPS and Imiquimod induced inflammation. |
| M9340 | IRAK-1-4 Inhibitor I | IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.3 μM and 0.2 μM, respectively. |
| M8100 | PF06650833 (Zimlovisertib) | PF06650833 (Zimlovisertib) is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). |
| M6469 | AS 2444697 | AS 2444697 is a potent and selective IRAK4 inhibitor. |
| M6258 | Emavusertib | Emavusertib (CA-4948) is a selective, potent and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) that regulates IRAK4 function in the TLR and IL-1R signaling cascades. It has good pharmacokinetic characteristics and antitumor activity in vitro and in vivo. |
| M56368 | HS-243 | HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC50 values of 20 and 24 nM. |
| M54868 | BIO-7488 | BIO-7488 is a potent, selective, oral active and CNS-penetrant IRAK4 inhibitor, with IC50 values of 0.6 nM and >30 μM for IRAK4 and hERG, respectively. |
| M54685 | IRAK4-IN-22 | IRAK4-IN-22 is an orally potent and selective potent IRAK4 inhibitor with IC50 values of 3 and 17 nM for IRAK4 and TAK1, respectively.In addition, IRAK4-IN-21 potently inhibits the production of IL-23 (IC50=0.10 µM), which may be useful in studies related to autoimmune diseases such as plaque psoriasis and psoriasis vulgaris. arthritis). |
| M54684 | HS271 | HS271 is an orally potent and selective IRAK4 inhibitor with an IC50 value of 7.2 μM. In addition, HS271 has superior in vitro enzymatic and cellular activities. |
| M54683 | PROTAC IRAK4 degrader-3 | PROTAC IRAK4 degrader-3 is a von Hippel-Lindau based IRAK4 degrader PROTAC. |
| M54682 | IRAK inhibitor 4 (trans) | IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4 and a potent inhibitor of IRAK4. |
| M54681 | IRAK4-IN-21 | IRAK4-IN-21 is an orally potent, selective, and potent IRAK4 inhibitor with IC50 values of 5 and 56 nM for IRAK4 and TAK1, respectively.IRAK4-IN-21 potently inhibits the production of IL-23 (IC50=0.17 µM) and may be useful in studies related to autoimmune diseases such as plaque psoriasis and psoriasis vulgaris. arthritis). |
| M54678 | KTX-582 | KTX-582 is a potent IRAK4 degrader with a DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively.In addition, KTX-582 induces apoptosis in MYD88MT DLBCL cells and tumor regression in vivo in a lymphoma model. |
| M54677 | KTX-951 | KTX-951 is a PROTAC (DC50= 18 nM) that targets the degradation of interleukin-1 receptor-associated kinase 4 (IRAK4) and exhibits promising anticancer activity. |
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