| Cat.No. | Name | Information |
|---|---|---|
| M54676 | PF-06426779 | PF-06426779 is a potent and selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with an IC50 value of 0.3 nM. |
| M54675 | Edecesertib | Edecesertib is a selective, orally active IRAK-4 inhibitor. In addition, Edecesertib has anti-inflammatory activity and may be used in studies related to rheumatoid arthritis (RA) and lupus erythematosus (LE). |
| M54674 | IRAK inhibitor 2 | IRAK inhibitor 2 is an interleukin-1 receptor-related kinase 4 (IRAK4) inhibitor. |
| M54673 | JH-X-119-01 hydrochloride | JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin 1 receptor-associated kinase 1 (IRAK1), which also ameliorates LPS-induced sepsis in mice. |
| M42004 | IRAK4-IN-26 | IRAK4-IN-26 is a IRAK4 inhibitor (IC50: 6.2 nM). |
| M42003 | Zomiradomide | Zomiradomide (IRAK degrader-1) is a potent IRAK degrader. |
| M42002 | IRAK4-IN-28 | IRAK4-IN-28 is an orally active IRAK4 inhibitor (IC50=8.9 nM). |
| M42001 | PROTAC IRAK4 degrader-8 | PROTAC IRAK4 degrader-8 is a PROTAC targeting to IRAK4 (IC50=15.5 nM). |
| M42000 | IRAK4-IN-27 | IRAK4-IN-27 is a potent, selective inhibitor of IRAK4, with IC50 of 8.7 nM. |
| M41999 | IRAK4-IN-24 | IRAK4-IN-24 is a potent IRAK4 inhibitor, with high clearance (Cl) and poor oral bioavailability. |
| M41998 | IRAK4-IN-25 | IRAK4-IN-25 is an orally acitve and potent IRAK4 inhibitor (IC50=7.3 nM), with low clearance (Cl=12 mL/min/kg). |
| M41291 | JNJ-1013 | JNJ-1013 is a potent and selective IRAK1 degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. |
| M29657 | IRAK4-IN-6 | IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma. |
| M29370 | HG-12-6 | HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation. |
| M29236 | GNE-2256 | GNE-2256 (molecule 19) is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM; IL-6 IC50=190 nM). |
| M29213 | GLPG2534 | GLPG2534 is an orally active and selective IRAK4 inhibitor, with IC50 values of 6.4 nM and 3.5 nM for human and mouse IRAK4. GLPG2534 can be used for the research of inflammatory skin diseases. |
| M27696 | IRAK inhibitor 1 | IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively. |
| M21784 | AZ1495 | AZ1495 is a weak base and orally active, potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with a Kd value of 0.0007 μM.AZ1495 has good physicochemical and kinase selectivity for IRAK4 and IRAK1, with IC50 values of 0.005 μM and 0.023 μM, respectively.AZ1495 is used in studies of diffuse large B-cell lymphoma (DLBCL). |
| M21388 | IRAK4-IN-20 | IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 may be used in studies of acute respiratory distress syndrome (ARDS). |
| M20764 | HS-243 | HS-243 is a highly potent interleukin-1 receptor-associated kinase (IRAK) inhibitor with IC50 of 24 nM, 20 nM and 0.5 μM for IRAK-1, IRAK-4 and TAK1, respectively. |
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