About 8 results found for searched term "I-138" (0.067 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1700 | Momelotinib (CYT387) | JAK |
| LM-1149; Momelotinib; CYT 11387 | ||
| Momelotinib (CYT387) is a small-molecule, ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM respectively. | ||
| M4805 | BIBX 1382 | EGFR/HER2 |
| Falnidamol | ||
| BIBX 1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). | ||
| M9088 | SRI-011381 hydrochloride | TGF-beta/Smad |
| SRI011381 HCl | ||
| SRI-011381 hydrochloride is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease. | ||
| M9522 | SRI-011381 | TGF-beta/Smad |
| SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease. | ||
| M10113 | BI01383298 | Sodium Channel |
| BI-01383298 | ||
| BI01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5). | ||
| M31189 | Influenza HA (126-138) | Anti-infection |
| Influenza HA (126-138) is a influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138, induces thymic and peripheral T-cell apoptosis. | ||
| M40555 | BI1387446 | STING |
| BI1387446 is a STING1 agonist that can be used in studies related to solid tumors. | ||
| M40720 | I-138 | Deubiquitinase |
| I-138 is an orally active, potent reversible inhibitor of USP1-UAF1, structurally related to ML323, showing synergistic binding to ubiquitin and mutually exclusive binding to ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 mono-ubiquitination in HAP-1 USP1 WT cells, and abrogates USP1 auto-cleavage in cells. | ||
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