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Influenza HA (126-138) 

Cat. No. M31189
Influenza HA (126-138)  Structure
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Biological Activity

Influenza HA (126-138) is a influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138, induces thymic and peripheral T-cell apoptosis.

Chemical Information
Molecular Weight 1324.31
Formula C52H81N19O22
CAS Number 207349-63-1
Solubility (25°C) Water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] T Yasuda, et al. Genes Cells. Importance of spatial activation of Cdc42 and rac small G proteins by frabin for microspike formation in MDCK cells

[2] N Nakamura, et al. Genes Cells. Phosphorylation of ERM proteins at filopodia induced by Cdc42

[3] E M Janssen, et al. J Immunol. Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide

[4] C A Scott, et al. Immunity. Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues

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