About 7 results found for searched term "GS 143" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6766 | GS 143 | IκB/IKK |
| GS 143 is a β-TrCP1 ligase inhibitor. | ||
| M27777 | (αR,8aS)-GSK1614343 | Ghrelin Receptor/GHSR |
| (αR,8aS)-GSK1614343 (compound 18a, d2) is a cyclized ghrelin antagonist with an pIC50 value of 8.4. (αR,8aS)-GSK1614343 shows a competitive antagonism of hGHSR1a with a mean pKb value of 8.06. | ||
| M57218 | GSK143 | Syk |
| GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. | ||
| M57216 | GSK143 dihydrochloride | Syk |
| GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. | ||
| M3484 | Dolutegravir | Integrase |
| GSK1349572 | ||
| Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. | ||
| M10828 | GSK778 | Epigenetic Reader Domain |
| iBET-BD1 | ||
| GSK778 (iBET-BD1) is a potent and selective inhibitor of the BD1 bromine domain of the BET protein,IC50 The values are 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1). GSK778 phenotyping the role of pan-BET inhibitors in cancer models. | ||
| M29173 | GSK3494245 | Parasite |
| DDD01305143 | ||
| GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 µM; enriched THP-1 extracts IC50=40µM). GSK3494245 exhibits attractive biological and biosafety properties. | ||
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