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(αR,8aS)-GSK1614343 (compound 18a, d2) is a cyclized ghrelin antagonist with an pIC50 value of 8.4. (αR,8aS)-GSK1614343 shows a competitive antagonism of hGHSR1a with a mean pKb value of 8.06.
| Molecular Weight | 487.44 |
| Formula | C22H23F6N5O |
| CAS Number | 1092476-84-0 |
| Form | Solid |
| Storage | Powder -20°C |
| Related Ghrelin Receptor/GHSR Products |
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| PF-6870961 hydrochloride
PF-6870961 hydrochloride is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. |
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