GPX4-IN-3 - Search Results | AbMole BioScience

About 4 results found for searched term "GPX4-IN-3" (0.122 seconds)

Cat.No.	Name	Target
M49462	GPX4-IN-3	Ferroptosis
	GPX4-IN-3 is a potent glutathione peroxidase 4 (GPX4) inhibitor that selectively induces ferroptosis.1 μM of GPX4-IN-3 inhibited 71.7% of GPX4 activity.
M8380	ML 210	Others
	Ml-210 is a selective, covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. Ml-210 binds GPX4 selenocysteine residues. ML210 has anticancer activity and has shown cytotoxic effects on melanoma, lung adenocarcinoma, fibrosarcoma and pancreatic cancer cell lines.
M42430	GPX4-IN-6	Glutathione Peroxidase
	GPX4-IN-6 is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM.
M43932	N6F11	Ferroptosis
	2-(chloromethyl)-6-(4-chlorophenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one
	N6F11 is a novel ferroptosis inducer that selectively triggers the ubiquitination degradation of GPX4 by binding to the specific structural domain of TRIM25, a ubiquitinated E3 ligase, which is expressed in tumor cells, leading to ferroptosis in cancer cells.