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 About 30 results found for searched term "GPR" (0.012 seconds)

Cat.No.  Name Information
M2020 GW9508 GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 has anti-inflammatory and anti-atherosclerotic activities. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener.
M2054 Fasiglifam (TAK-875) Hemihydrate Fasiglifam (TAK-875) Hemihydrate is a novel, orally available, selective GPR40 agonist.
M2384 AMG-837 AMG 837 is a potent, orally bioavailable GPR40 agonist with EC50 of 14 nM.
M3321 GSK1292263 GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes.
M3632 MBX-2982 MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 diabetes.
M3766 AR-231453 AR-231453 is a potent, selective G-protein coupled receptor 119 (GPR119) agonist (EC50 = 0.68 nM).
M3771 PSN632408 PSN632408 is a novel, selective and small-molecule agonist of human and mouse GPR119 with EC50 values of 5.6±0.99 μM and 7.9±0.7 μM, respectively.
M3773 PSN-375963 PSN 375963 is an effective GPR119 agonist with EC50 of 8.4 and 7.9 μM for human and mice, respectively. PSN 375963 showed similar potency to endogenous oleoylethanolamide (OEA).
M3916 Vincamine Vincamine can be used as a peripheral vascular dilator (Vasodilator) to selectively regulate cerebral microvascular circulation. Vincamine is a GPR40 agonist that plays a beta-cell protective role by improving beta-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine can improve glucose homeostasis in vivo and has potential in the study of type 2 diabetes (T2DM).
M3950 APD668 APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.
M4065 Ginsenoside-Rb2 Ginsenoside Rb2 is one of the main bioactive components of ginseng extract. Ginsenoside Rb2 can up-regulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.
M4512 Tectoridin Tectoridin is an isoflavone isolated from Maackia Amurensis. Tectoridin is a phytoestrogen that activates estrogen and thyroid hormone receptors. Tectoridin exerts estrogenic effects through the ER dependent genomic pathway and the GPR30 dependent non-genomic pathway.
M4836 G-1 G-1 is a potent and selective GPR30 receptor agonist (Ki = 11 nM, EC50 = 2 nM).
M5040 APD597 APD597 is a GPR119 agonist used in the study of type 2 diabetes mellitus. The EC50 of hGPR119 is 46 nM.
M5292 GPR120-IN-1 GPR120-IN-1 is a selective Gpr120 agonist with a logEC50 of 7.62.
M6141 NIBR189 NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).
M6150 GPR39-C3 GPR39-C3 is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
M6387 Abn-CBD Abn-CBD is a selective GPR55 agonist; neurobehaviorally inactive.
M6401 Acifran Acifran is a hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors.
M6428 AM 4668 AM 4668 is a potent FFA1 (GPR40) agonist.
M6435 AMG 837 hemicalcium salt AMG 837 hemicalcium salt is a potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist.
M6454 AR420626 AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3, GPR41) with IC50 of 117 nM.
M6466 AS 1269574 AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic β cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research.
M6468 AS 2034178 AS 2034178 is a selective FFA1 (GPR40) agonist.
M6849 JNJ 63533054 JNJ-63533054 is a potent, selective, orally active GPR139 agonist.JNJ-63533054 is more selective for GPR139 than other GPCR, ion channel and transporter proteins.JNJ-63533054 can cross the blood-brain barrier (BBB).
M6921 LUF 6283 LUF 6283 is a hCA 2 (GPR109A) partial agonist.
M6945 MEDICA 16 MEDICA 16 is a fFA1 (GPR40) agonist; also inhibits ATP citrate lyase.
M7004 MS 21570 MS 21570 is a gPR171 antagonist.
M7080 Oleylethanolamide Oleylethanolamide is a lipid mediator, anorexic actions; also GPR55 and PPARα agonist.
M7319 Sphingosine-1-phosphate Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors.

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