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About 30 results found for searched term "GPR" (0.012 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M2020 | GW9508 | GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 has anti-inflammatory and anti-atherosclerotic activities. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. |
| M2054 | Fasiglifam (TAK-875) Hemihydrate | Fasiglifam (TAK-875) Hemihydrate is a novel, orally available, selective GPR40 agonist. |
| M2384 | AMG-837 | AMG 837 is a potent, orally bioavailable GPR40 agonist with EC50 of 14 nM. |
| M3321 | GSK1292263 | GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes. |
| M3632 | MBX-2982 | MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 diabetes. |
| M3766 | AR-231453 | AR-231453 is a potent, selective G-protein coupled receptor 119 (GPR119) agonist (EC50 = 0.68 nM). |
| M3771 | PSN632408 | PSN632408 is a novel, selective and small-molecule agonist of human and mouse GPR119 with EC50 values of 5.6±0.99 μM and 7.9±0.7 μM, respectively. |
| M3773 | PSN-375963 | PSN 375963 is an effective GPR119 agonist with EC50 of 8.4 and 7.9 μM for human and mice, respectively. PSN 375963 showed similar potency to endogenous oleoylethanolamide (OEA). |
| M3916 | Vincamine | Vincamine can be used as a peripheral vascular dilator (Vasodilator) to selectively regulate cerebral microvascular circulation. Vincamine is a GPR40 agonist that plays a beta-cell protective role by improving beta-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine can improve glucose homeostasis in vivo and has potential in the study of type 2 diabetes (T2DM). |
| M3950 | APD668 | APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively. |
| M4065 | Ginsenoside-Rb2 | Ginsenoside Rb2 is one of the main bioactive components of ginseng extract. Ginsenoside Rb2 can up-regulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects. |
| M4512 | Tectoridin | Tectoridin is an isoflavone isolated from Maackia Amurensis. Tectoridin is a phytoestrogen that activates estrogen and thyroid hormone receptors. Tectoridin exerts estrogenic effects through the ER dependent genomic pathway and the GPR30 dependent non-genomic pathway. |
| M4836 | G-1 | G-1 is a potent and selective GPR30 receptor agonist (Ki = 11 nM, EC50 = 2 nM). |
| M5040 | APD597 | APD597 is a GPR119 agonist used in the study of type 2 diabetes mellitus. The EC50 of hGPR119 is 46 nM. |
| M5292 | GPR120-IN-1 | GPR120-IN-1 is a selective Gpr120 agonist with a logEC50 of 7.62. |
| M6141 | NIBR189 | NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional). |
| M6150 | GPR39-C3 | GPR39-C3 is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively. |
| M6387 | Abn-CBD | Abn-CBD is a selective GPR55 agonist; neurobehaviorally inactive. |
| M6401 | Acifran | Acifran is a hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors. |
| M6428 | AM 4668 | AM 4668 is a potent FFA1 (GPR40) agonist. |
| M6435 | AMG 837 hemicalcium salt | AMG 837 hemicalcium salt is a potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist. |
| M6454 | AR420626 | AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3, GPR41) with IC50 of 117 nM. |
| M6466 | AS 1269574 | AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic β cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research. |
| M6468 | AS 2034178 | AS 2034178 is a selective FFA1 (GPR40) agonist. |
| M6849 | JNJ 63533054 | JNJ-63533054 is a potent, selective, orally active GPR139 agonist.JNJ-63533054 is more selective for GPR139 than other GPCR, ion channel and transporter proteins.JNJ-63533054 can cross the blood-brain barrier (BBB). |
| M6921 | LUF 6283 | LUF 6283 is a hCA 2 (GPR109A) partial agonist. |
| M6945 | MEDICA 16 | MEDICA 16 is a fFA1 (GPR40) agonist; also inhibits ATP citrate lyase. |
| M7004 | MS 21570 | MS 21570 is a gPR171 antagonist. |
| M7080 | Oleylethanolamide | Oleylethanolamide is a lipid mediator, anorexic actions; also GPR55 and PPARα agonist. |
| M7319 | Sphingosine-1-phosphate | Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. |
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