MRGPRX4 modulator-2 is a potent MRGPR X4 modulator with antagonistic activity against MRGPRX4 and an IC50 < 100 nM.MRGPRX4 modulator-2 can be used in studies related to autoimmune diseases.
| Molecular Weight | 348.68 |
| Formula | C15H9ClF4O3 |
| CAS Number | 2492595-24-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related MRGPR Products |
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| Neuropeptide AF (cattle)
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. |
| (S)-ZINC-3573
(S)-ZINC-3573 is an inactive enantiomer of ZINC-3573 and a selective MRGPRX2 agonist. In addition, (S)-ZINC-3573 and (R)-ZINC-3573 are potent internal control probes that can be used to study the biology of unique receptors in primates. |
| MRGPRX4 modulator-1
MRGPRX4 modulator-1 is a potent MAS-associated G-protein receptor X4 (MRGPRX4) modulator with antagonistic activity against MRGPR4 and an IC50 < 100 nM.MRGPRX4 modulator-1 can be used in studies related to MRGPRX4-dependent disorders, such as itch, pain, and autoimmune diseases. |
| PAMP-12
PAMP-12 is an endogenous peptide and potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM) that induces hypotension by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. |
| MRGPRX1 agonist 1
MRGPRX1 agonist 1 is a potent Mas-related G protein-coupled receptor X1 (MRGPRX1) agonist with an EC50 value of 50 nM and is inactive against MRGPRC11. |
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