About 6 results found for searched term "GNF-2" (0.052 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2571 | GNF-2 | Src-bcr-Abl |
| GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells. | ||
| M6979 | ML348 | Phospholipase |
| GNF-Pf-1127; ML-348 | ||
| ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM. | ||
| M10823 | GNF-6231 | Others |
| GNF-6231 is a strong, selective, oral-capable Porcupine inhibitor capable of blocking the Wnt signaling pathway. | ||
| M21035 | LCH-7749944 | PAK |
| GNF-PF-2356 | ||
| LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4. | ||
| M21230 | GNF2133 | DYRK |
| GNF2133 is a potent, selective, orally active DYRK1A inhibitor with IC50s of 0.0062 and >50 µM for DYRK1A and GSK3β, respectively. GNF2133 has potential for the study of type 1 diabetes. | ||
| M28866 | GNF6702 | Parasite |
| GNF6702 is a selective inhibitor of the kinetoplastid proteasome. GNF6702 clears parasites in murine models of leishmaniasis, Chagas disease, and human African trypanosomiasis. | ||
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