About 9 results found for searched term "CD73-IN-1" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M22030 | CD73-IN-1 | Others |
| CD73-IN-1 | ||
| M9910 | CDKI-73 | CDK |
| CDKI73; Asnuciclib; LS-007 | ||
| Cdki-73 (LS-007) is an orally active and highly effective CDK9 inhibitor with Ki values of 4 nM, 4 nM and 3 nM against CDK9, CDK1 and CDK2, respectively. Cdki-73 down-regulates phosphorylation of RNA polymerase II. Cdki-73 is also an inhibitor of Rab11. | ||
| M10186 | Leniolisib | PI3K |
| CDZ173 | ||
| Leniolisib (CDZ173) is a first-in-class (first-in-class), potent, selective PI3Kδ inhibitor with an IC50 value of 11 nM. Leniolisib has the potential for immunodeficiency disorders treatment. | ||
| M10772 | AB-680 | Immunology/Inflammation |
| AB-680 is a potent, reversible, selective CD73 (extracellular nucleotide enzyme) inhibitor of hCD73 Ki The value is 4.9 pM, which is more than 10,000 times more selective than the associated extracellular nucleotide CD39. Has antitumor activity. | ||
| M11275 | PSB-12379 | Others |
| Psb-12379 is a nucleotide analogue and a potent ECTO-5 '-nucleotidase (CD73) inhibitor with Kis values of 9.03 nM (rat) and 2.21 nM (human). | ||
| M29440 | TL12-186 | PROTAC |
| TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM). | ||
| M41259 | CDD-1733 | Anti-infection |
| CDD-1733 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor with a Ki of 12 nM. | ||
| M41959 | BK50164 | Immunology/Inflammation |
| BK50164 is a potent CD73 inhibitor with an IC50 value of 13.089 µM. | ||
| M43397 | Leniolisib phosphate | PI3K |
| Leniolisib (CDZ173) phosphate is a first-in-class, potent and selective PI3Kδ inhibitor with an IC50 value of 11 nM.Leniolisib is more selective for PI3K-δ than PI3K-α (28-fold), PI3K-β (43-fold) and PI3K-γ (257-fold). -γ (257-fold). In a cellular assay, Leniolisib decreased pAKT pathway activity and inhibited the proliferation and activation of B and T cell subsets. | ||
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