About 8 results found for searched term "C21" (0.14 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6257 | ONC212 | GPR/FFAR |
| ONC212, a fluorinated-ONC201 analogue, is broadly efficacious across most solid tumors and hematological malignancies in the low nanomolar range and has robust anti-leukemic activity. | ||
| M13907 | AT2 receptor agonist C21 | Angiotensin Receptor |
| AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively. | ||
| M20982 | BNC210 | AChR/AChE |
| H-Ile-Trp-OH, IW-2143 | ||
| BNC210 (H-Ile-Trp-OH, IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR). | ||
| M25496 | DRI-C21045 | TNF Receptor |
| DRI-C21045 is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively. | ||
| M27987 | CC214-2 | mTOR |
| CC214-2 is an oral active and selective mTOR kinase inhibitor. CC214-2 targets to both of mTORC1 (pS6) and mTORC2 (pAktS473). CC214-2 induces autophagy, which is a potential target for host-directed therapy (HDT) in tuberculosis. CC214-2 exhibits synergistic bactericidal and sterilizing activity agasinst tuberculosis (TB), and shortens the treatment duration. CC214-2 also inhibits Rapamycin-resistant signaling and the growth of glioblastomas in vitro and in vivo. | ||
| M41376 | DRI-C21041 | TNF Receptor |
| DRI-C21041 is a CD40/CD40L interaction inhibitor, with an IC50 of 0.31 μM. | ||
| M53315 | C21 | Histone Methyltransferase |
| C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM. | ||
| M54819 | TC-2153 | 5-HT Receptor |
| TC2153 | ||
| TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP). TC-2153 also inhibits 5-HT2A receptor-mediated signaling. | ||
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