About 7 results found for searched term "AZ-TAK1" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42130 | AZ-TAK1 | MAPKAPK2/MAP3K/MAP4K |
| AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines. | ||
| M2106 | Azilsartan | Angiotensin Receptor |
| TAK-536 | ||
| Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. | ||
| M3160 | Vilazodone | 5-HT Receptor |
| EMD 68843, SB 659746A | ||
| Verazodone (EMD 68843; SB 659746A) is a complex serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently being evaluated in clinical studies for major depression. | ||
| M5493 | Cefoperazone | Antibiotic |
| Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM. | ||
| M20395 | Tetrabenazine (Xenazine) | Dopamine Receptor |
| Tetrabenazine(Nitoman, Xenazine) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2 Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2. | ||
| M27684 | Lazabemide hydrochloride | Monoamine Oxidase |
| Ro 19-6327 hydrochloride | ||
| Lazabemide hydrochloride (Ro 19-6327 hydrochloride) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease. | ||
| M41896 | Firazorexton hydrate | OX Receptor |
| Firazorexton hydrate (TAK-994) is a potent, brain-penetrant, and orally active orexin type 2 receptor (OX2R) agonist (EC50: 19 nM). | ||
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