About 10 results found for searched term "740 Y-P" (0.099 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9389 | 740 Y-P | PI3K |
| PDGFR 740Y-P; 740YPDGFR | ||
| 740 Y-P is a potent and cell permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone. | ||
| M1759 | GSK1120212 (Trametinib) | MEK |
| JTP-74057, GSK212 | ||
| Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis. | ||
| M3268 | BMS-740808 | Factor Xa |
| BMS-740808 is a highly potent, selective inhibitor of blood coagulation factor Xa (fXa) with Ki with 0.03 nM. | ||
| M6935 | LY 354740 | Others |
| Eglumegad; Eglumetad | ||
| LY 354740 is a potent and highly selective group II mGlu agonist. | ||
| M10498 | CCG-222740 | Ras |
| CCG-222740 is a selective, orally active Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. | ||
| M10860 | MRK-740 | Histone Methyltransferase |
| MRK-740 is a potent, selective, substrate-competitive PRDM9 histone methyltransferase inhibitor,IC50 80 nM. MRK-740 is more selective to PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 Reduces PRDM9-Dependent H3K4 Trimethylation (IC50 0.8 μM). | ||
| M10905 | Pralnacasan | Caspase |
| VX-740; HMR 3480 | ||
| Pralnacasan (VX-740) is a potent, selective, non-peptide inhibitor with an oral active interleukin 1β-convertase (ICE, caspase 1) inhibitor,Ki 1.4 nM. Pralnacasan inhibits pro-inflammatory cytokines IL-18, IL-1β, and IFN-γ. Pralnacasan has the potential to be used in the study of osteoarthritis and rheumatoid arthritis. | ||
| M30844 | CPUY074020 | Histone Methyltransferase |
| CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity. | ||
| M41872 | Eglumegad hydrochloride | GluR |
| Eglumegad (LY354740) hydrochloride is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. | ||
| M55811 | PSI-7409 tetrasodium | Anti-infection |
| PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively. | ||
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