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740 Y-P

Cat. No. M9389
740 Y-P Structure
Synonym:

PDGFR 740Y-P

Size Price Availability Quantity
1mg USD 115  USD115 In stock
5mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

740 Y-P is a potent and cell permeable PI3K activator.

Product Citations
Chemical Information
Molecular Weight 3270.70
Formula C141H222N43O39PS3
CAS Number 1236188-16-1
Solubility (25°C) Water ≥ 1 mg/mL
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Derossi D, et al. Biochem Biophys Res Commun. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide.

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Keywords: 740 Y-P, PDGFR 740Y-P supplier, Cell Culture, inhibitors, activators


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