About 12 results found for searched term "64-99-3" (0.168 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2587 | JW 55 | PARP |
| JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively. | ||
| M4577 | Segetalin-B | Peptides |
| Segetalin-B is an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. | ||
| M5267 | E7449 | PARP |
| Stenoparib; 2X-121; MGI25036 | ||
| E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. | ||
| M6491 | BAY 58-2667 hydrochloride | Guanylate Cyclase |
| BAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator. | ||
| M25612 | Elironrasib | Ras |
| RMC-6291 | ||
| Elironrasib is an orally active and covalent inhibitor of KRASG12C(ON). Elironrasib prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. Elironrasib inhibits ERK signaling and induced apoptosis in KRASG12C-mutant H358 cells. Elironrasib also inhibits the proliferation of KRASG12C mutant cells with a median IC50 of 0.11 nM. | ||
| M11427 | RM-018 | Ras |
| INDEX NAME NOT YET ASSIGNED | ||
| RM-018 is an inhibitor of the active state of KRASG12C. Rm-018 retains the ability to bind and inhibit KRASG12C/Y96D. Rm-018 combines with GTP-bound to activate the [" RAS(ON) "] state of KRASG12C. | ||
| M22229 | Etimizol | Others |
| Etimizol | ||
| M43389 | FD274 | PI3K |
| FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. | ||
| M43765 | Calyxin B | Others |
| Calyxin B can be extracted from the seeds of Alpinia blepharocalyx. | ||
| M50772 | CFP10 (71–85) | Others |
| CFP10 (71–85) is a biological active peptide. | ||
| M53136 | (Des-Pyr1, Des-Gly10, D-Leu6, Pro-NHEt9)-LHRH | LHRH/GnRH |
| (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. | ||
| M58666 | GSK4418959 | DNA/RNA Synthesis |
| IDE275 | ||
| GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. | ||
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