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JW55

Cat. No. M2587
JW55 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 110  USD110 In stock
10mg USD 100  USD100 In stock
50mg USD 335  USD335 In stock
100mg USD 560  USD560 In stock
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Quality Control & Documentation
Biological Activity

JW 55 efficacy causes stabilization of Axin2 . JW 55 also decreases canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW 55 inhibits the β-catenin signaling pathway. It Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; JW 55 reduces cell cycle progression and proliferation in SW480 cells in vitro.

Chemical Information
Molecular Weight 434.48
Formula C25H26N2O5
CAS Number 664993-53-7
Solubility (25°C) DMSO 50 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Waaler J, et al. Cancer Res. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

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