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JW 55 efficacy causes stabilization of Axin2 . JW 55 also decreases canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW 55 inhibits the β-catenin signaling pathway. It Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; JW 55 reduces cell cycle progression and proliferation in SW480 cells in vitro.
| Molecular Weight | 434.48 |
| Formula | C25H26N2O5 |
| CAS Number | 664993-53-7 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PARP Products |
|---|
| 2-Methylquinazolin-4-ol
2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with IC50 of 0.20 mM. |
| DPQ
DPQ is a potent PARP-1 inhibitor. |
| OUL232
OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. |
| AZ3391
AZ3391 is a potent inhibitor of PARP. |
| PARP1-IN-5
PARP1-IN-5 is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). |
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