About 3 results found for searched term "6-Mercaptopurine" (0.079 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3258 | Thioguanine | DNA/RNA Synthesis |
| 6-Thioguanine; 6-TG; 2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol | ||
| Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients. | ||
| M5375 | 6-Mercaptopurine (6-MP) Monohydrate | DNA/RNA Synthesis |
| 6-MP | ||
| Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting phosphoribose pyrophosphate amide transferase (PRPP amide transferase). PRPP amide transferase is a rate-limiting enzyme formed by purine. It alters the synthesis and function of RNA and DNA. Mercaptopurine also interferes with nucleoside tautomies and glycoprotein synthesis. | ||
| M5771 | 6-Mercaptopurine | DNA/RNA Synthesis |
| 6-MP | ||
| 6-Mercaptopurine (6-MP) inhibits neopurine synthesis by incorporating methyltransferase metabolites of Mercaptopurine into DNA and RNA. | ||
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