About 30 results found for searched term "6-FAM SE" (0.088 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21712 | 6-FAM SE | Fluorescent Dye |
| 6-FAM SE is another isomer of carboxyfluorescein. 6-FAM, SE is mainly used in sequencing of nucleic acids and labeling nucleotides. | ||
| M21715 | 5(6)-FAM SE | Fluorescent Dye |
| 5(6)-Carboxyfluorescein succinimidyl ester mixed isomers | ||
| 5(6)-FAM SE is an amine-reactive green fluorescent dye widely used for labeling proteins or other molecules that contain a primary or secondary aliphatic amine. | ||
| M3569 | AST-1306 (TsOH) | EGFR/HER2 |
| AST-6; Allitinib tosylate | ||
| AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases, | ||
| M4843 | SU6656 | Src-bcr-Abl |
| SU-6656 | ||
| SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively. | ||
| M11359 | Recombinant Human IL-6R (CHO) | Cytokines and Growth Factors |
| IL-6RA; IL-6R1; CD126; IL-6RA | ||
| Interleukin-6 Receptor Alpha belongs to the type I cytokine receptor family. It binds specifically to IL-6 and depends on gp130 to transmit signals. Measured in a cell proliferation assay using M1 cells in the presence of 10.0 ng/ mL human IL-6, the ED50 is < 0.2 μg/mL. | ||
| M6704 | EHT 1864 2HCl | Ras |
| EHT 1864 is a potent inhibitor of Rac family GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. | ||
| M7197 | RMM 46 | Others |
| RMM 46 is a mSK/RSK family kinase inhibitor. | ||
| M8529 | A-366 | Histone Methyltransferase |
| A366 | ||
| A-366 is a potent and highly selective peptide-competitive inhibitor of histone methyltransferase G9a, with IC50s of 3.3 nM and 38 nM for G9a and GLP, respectively, and is more than 1,000-fold selective for G9a and GLP over 21 other methyltransferases. A-366 is also a potent inhibitor of Spindlin1-H3K4me3 interaction (IC50=182.6 nM).A-366 shows high affinity for human H3R (Ki=17 nM) and exhibits subtype selectivity between subpopulations of the histaminergic and dopaminergic receptor families. It can be used for induction and maintenance of pluripotent stem cells in mice. | ||
| M8639 | STK16-IN-1 | Others |
| STK16-IN-1 is a cell-permeable pyrrolonaphthyridinone compound that acts as an ATP-competitive inhibitor against NAK (Numb Associated Kinase) family serine/threonine kinase STK16 (IC50/substrate = 0. | ||
| M9889 | PCI-29732 | BTK |
| PCI29732 | ||
| PCI-29732 is a potent, reversible BTK inhibitor with Kiapp values of 8.2, 4.6, and 2.5 nM for BTK, Lck, and Lyn, respectively, and has only modest inhibitory activity against Itk, another Tec family kinase. In addition, PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP binding site of ABCG2. | ||
| M10760 | GSK620 | Epigenetic Reader Domain |
| GSK620 is a potent orally active pan-BD2 inhibitor with good broad-spectrum selectivity, developability, and in vivo oral pharmacokinetics, and is highly selective against the BET-BD2 family protein, with a selectivity of more than 200 times that of all other BET bromodomains. GSK620 exhibits an anti-inflammatory phenotype in human whole blood. | ||
| M10768 | SKF83959 | Others |
| SKF83959 is a potent selective dopamine D1-like Receptor partial agonist. SKF83959 Ki to rats D1，D5，D2AND D3 The values are 1.18, 7.56, 920, and 399 nM, respectively. SKF83959 is a potent sigma (σ)-1 receptor allosteric modulator. SKF83959 belongs to the benzazepine family and has an improving effect on cognitive dysfunction. SKF83959 can be used to study Alzheimer's disease and depression. | ||
| M10832 | HPK1-IN-7 | MAPKAPK2/MAP3K/MAP4K |
| HPK1-IN-7 is a potent inhibitor of the orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) (IC50=2.6 nM), with excellent family and kinase group selectivity. The HPK1-IN-7 is selective for IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 combined with anti-PD1 has shown powerful efficacy in MC38 cogenic tumor models. | ||
| M10927 | GFB-8438 | TRP Channel |
| GFB-8438 is a potent subtype selective TRPC5 inhibitor against hTRPC5 and hTRPC4 IC50 0.18 and 0.29 μM, respectively. GFB-8438 has good selectivity for TRPC6, other members of the TRP family, NaV1.5, and limited activity against hERG channels. Protective effect of GFB-8438 on mouse podocytes. | ||
| M11149 | Uniconazole | Plant growth regulators |
| Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols. | ||
| M13536 | VRT-043198 | Caspase |
| VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. | ||
| M13788 | Hoechst 33258 analog 6 | Fluorescent Dye |
| Hoechst 33258 analog 6 is a anglog of Hoechst stains(Hoechst 33258), which are part of a family of blue fluorescent dyes used to stain DNA. | ||
| M14888 | EHT 1610 | Others |
| EHT 1610 is a strong inhibitor of DYRK’s family kinases, with IC50s of 0.36, 0.59 nM for DYRK1A and DYRK1B, respectively. | ||
| M14911 | CH6953755 | Src-bcr-Abl |
| CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo. | ||
| M19986 | Recombinant Human CXCL6 (HEK293, C-6His) | Cytokines and Growth Factors |
| C-X-C Motif Chemokine 6; Chemokine Alpha 3 | ||
| Chemokine (C-X-C-Motif) Ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family. CXCL6 can promote the release of MMP-9 from granulocytes indicating its potential role as an inflammatory mediator. It functionally uses both of the IL-8/CXCL8 receptors to chemoattract neutrophils but that is structurally most related to epithelial cell-derived neutrophil attractant-78 (ENA-78)/CXCL5. Accession: P80162. | ||
| M21402 | Recombinant Mouse IL-27 (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-27 subunit alpha; IL-27 subunit alpha | ||
| IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. Recombinant Mouse Interleukin-27 Subunit Alpha and Interleukin-27 Subunit Beta expressed the target gene encoding Tyr19-Pro228&Phe29-Ser234 with a 6His tag at the C-terminus. | ||
| M21442 | Recombinant Mouse G-CSF (CHO) | Cytokines and Growth Factors |
| CSF3; C17orf33; CSF3OS; GCSF | ||
| Granulocyte Colony-Stimulating Factor (G-CSF), also known as CSF-3 and MGI-1G, is a cytokine and hormone belonging to the IL-6 superfamily. It is expressed by monocytes, macrophages, endothelial cells, fibroblasts and bone marrow stroma. ED50 < 0.02 ng/ml | ||
| M21705 | Recombinant Mouse IL-17F (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-17F | ||
| Recombinant Mouse Interleukin-17F is produced by Mammalian expression system and the target gene encoding Arg29-Ala161 is expressed with a 6His tag at the C-terminus. Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. | ||
| M21710 | 6-FAM | Fluorescent Dye |
| 6-Carboxyfluorescein; 6-CF | ||
| 6-FAM (6-Carboxyfluorescein) contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. | ||
| M24634 | Luspatercept | TGF-beta/Smad |
| ACE-536; luspatercept-aamt | ||
| Luspatercept (ACE-536) is a first-in-class recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia. | ||
| M24760 | Tavolixizumab | TNF Receptor |
| MEDI 0562; Tavolimab | ||
| Tavolixizumab (MEDI 0562; Tavolimab) is a human monoclonal antibody to TNFRSF4 (TNF receptor superfamily member 4, OX40, CD134) for use in cancer immunology research. | ||
| M24844 | Omburtamab | Others |
| Omburtamab is an anti-CD276 (also known as B7-H3) monoclonal antibody, CD276 is a B7/CD28 immunoglobulin superfamily member expressed among solid human tumours. Omburtamab can bind tumor tissues and be used in various cancers research. | ||
| M25015 | Revdofilimab | OX Receptor |
| ABBV-368 | ||
| Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells. | ||
| M28063 | Famitinib malate | VEGFR/PDGFR |
| SHR1020 malate | ||
| Famitinib (SHR1020) malate, an orally active multi-targeted kinase inhibitor, inhibits the activity of c-kit, VEGFR-2 and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM and 6.6 nM, respectively. Famitinib malate induces cell apoptosis. Famitinib malate exerts powerful antitumor activity in human gastric cancer cells and xenografts, it can be used for the research of cancer. | ||
| M28131 | Rifalazil | DNA/RNA Synthesis |
| KRM-1648; ABI-1648 | ||
| Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml. | ||
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