5(6)-FAM SE is an amine-reactive green fluorescent dye widely used for labeling proteins or other molecules that contain a primary or secondary aliphatic amine.
|Solubility (25°C)||DMSO 50 mg/mL|
|Storage||-20°C, protect from light|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Jagpreet S Nanda, et al. Methods Enzymol. Labeling a protein with fluorophores using NHS ester derivitization
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ANTS is a fluorescent dye. ANTS and DPX are encapsulated in liposomes can be an effective approach for measuring membrane leakage.
Pafolacianine, also known as OTL0038 and OTL-38, is a folate receptor-directing imaging agent. Pafolacianine (OTL 38) is used in detecting ovarian cancer lesions.
Phalloidin-retramethylrhodamine is an orange fluorescent probe (ex/em = 546/575 nm) that selectively binds to F-actin. It can be used to localize actin filaments in living or fixed cells, as well as for visualizing individual actin filaments in vitro.
6-TAMRA has been a widely used fluorophore for preparing bioconjugates, especially fluorescent antibody and avidin derivatives used in immunochemistry. The carboxylic acid of 6-TAMRA has also achieved prominence as a dye for oligonucleotide labeling and automated DNA sequencing applications.
5-TAMRA is a pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.
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