4-Hydroxytamoxifen - Search Results

About 4 results found for searched term "4-Hydroxytamoxifen" (0.126 seconds)

Cat.No.	Name	Target
M7839	(E/Z)-4-Hydroxytamoxifen	Estrogen Receptor
	Afimoxifene
	(E/Z)-4-Hydroxytamoxifen is the racemate of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen and a modulator of the estrogen receptor (ER).
M10252	4-Hydroxytamoxifen	Estrogen Receptor
	(Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene
	4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM).
M20777	GSK5182	Estrogen Receptor
	GSK5182 is a 4-Hydroxytamoxifen analog and a highly potent, selective, orally active estrogen-related receptor gamma (ERRγ) inverse agonist with an IC50 value of 79 nM.GSK5182 does not interact with other nuclear receptors, including ERRα and ERα. In addition, GSK5182 inhibits proinflammatory cytokine-induced catabolic factors and increases ROS production in liver cancer cells. cytokine-induced catabolic factors and increased ROS production in hepatocellular carcinoma cells.
M29371	SNIPER(ER)-87	PROTAC
	SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation.