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4-Hydroxytamoxifen

Cat. No. M10252
4-Hydroxytamoxifen Structure
Synonym:

(Z)-4-Hydroxytamoxifen

Size Price Availability
5mg USD 83  USD83 Out of stock
25mg USD 225  USD225 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 387.51
Formula C26H29NO2
CAS Number 68047-06-3
Purity >99%
Solubility Ethanol 20 mg/mL
DMSO 20 mg/mL
Storage at -20°C
References

[1] Juliette Gauduchon, et al. Clin Cancer Res. 4-Hydroxytamoxifen inhibits proliferation of multiple myeloma cells in vitro through down-regulation of c-Myc, up-regulation of p27Kip1, and modulation of Bcl-2 family members

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Keywords: 4-Hydroxytamoxifen, (Z)-4-Hydroxytamoxifen supplier, Estrogen Receptor, inhibitors

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