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SNIPER(ER)-87 

Cat. No. M29371

All AbMole products are for research use only, cannot be used for human consumption.

SNIPER(ER)-87  Structure

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Biological Activity

SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation.

Chemical Information
Molecular Weight 1044.3
Formula C59H73N5O10S
CAS Number 2222354-91-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Nobumichi Ohoka, et al. J Biol Chem. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation

[2] Nobumichi Ohoka, et al. J Biol Chem. In Vivo Knockdown of Pathogenic Proteins via S pecific and N ongenetic I nhibitor of Apoptosis Protein (IAP)-dependent P rotein Er asers (SNIPERs)

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Keywords: SNIPER(ER)-87  supplier, PROTAC, inhibitors, activators

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