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SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation.
| Molecular Weight | 1044.3 |
| Formula | C59H73N5O10S |
| CAS Number | 2222354-91-6 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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