About 10 results found for searched term "β-catenin-IN-7" (0.36 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43565 | β-catenin-IN-7 | Wnt/beta-catenin |
| β-catenin-IN-7 is a β-catenin inhibitor. | ||
| M4829 | WIKI4 | Wnt/beta-catenin |
| WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) that inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM). | ||
| M6855 | JW 74 | Wnt/beta-catenin |
| JW 74 is a wnt pathway inhibitor, with an IC50 of 420 nM. JW 74 targets the β-catenin destruction complex (GSK-3 beta /AXIN/APC). JW 74 increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. | ||
| M14939 | β-catenin-IN-2 | Wnt/beta-catenin |
| β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer. | ||
| M21154 | NRX-252114 | Others |
| NRX-25211 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-25211 was able to promote the degradation of mutant β catenin degradation. | ||
| M29741 | ZW4864 free base | Wnt/beta-catenin |
| ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. | ||
| M29742 | ZW4864 | Wnt/beta-catenin |
| ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. | ||
| M29815 | NRX-103094 | PROTAC |
| NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM. | ||
| M43561 | YW2036 | Wnt/beta-catenin |
| YW2036 is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM. | ||
| M58585 | Wnt/β-catenin agonist 1 | Wnt/beta-catenin |
| Wnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM. | ||
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