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ZXH-1-161

Cat. No. M21151
ZXH-1-161  Structure
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Quality Control & Documentation
Biological Activity

ZXH-1-161 is a potent cereblon (CRBN) regulator with an IC50 of 39 μM in wild-type MM1.S cells. ZXH-1-161 has selective degradation activity against GSPT1. ZXH-1-161 can be used in the study of multiple myeloma.

Chemical Information
Molecular Weight 468.51
Formula C26H24N6O3
CAS Number 2407654-51-5
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related Ligand for E3 Ligase Products
2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2,6-Bis(benzyloxy)pyridine-3-boronic acid

2,6-Bis(benzyloxy)pyridine-3-boronic acid

2,6-Bis(benzyloxy)-3-bromopyridine

2,6-Bis(benzyloxy)-3-bromopyridine

2,6-bis(benzyloxy)pyridin-3-amine

2,6-bis(benzyloxy)pyridin-3-amine

3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione

3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione

  Catalog
Abmole Inhibitor Catalog




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