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ZL006 inhibits the ischemia-induced interaction of nNOS with postsynaptic density protein-95 (PSD-95), preventing glutamate-induced excitotoxicity and cerebral ischemic damage. It does not inhibit nNOS itself. ZL006 is brain penetrant, and has been tested in both rat and mouse models of stroke.
| Molecular Weight | 328.15 |
| Formula | C14H11Cl2NO4 |
| CAS Number | 1181226-02-7 |
| Form | Solid |
| Solubility (25°C) | DMSO: ≥5 mg/mL (warmed to 60° C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Wen-Yuan Tao, et al. Neuroprotective effects of ZL006 in Aβ 1-42-treated neuronal cells
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