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Zingerone (Vanillylacetone) is a non-toxic methoxyphenol obtained from ginger. It has anti-inflammatory, anti-diabetes, anti-lipid allergy, anti-diarrhea, anti-spasticity and anti-tumor activities. Zingerone reduces oxidative stress and inflammation and down-regulates NF-κB signaling. Zingerone acts as an anti-mitotic agent and inhibits the growth of neuroblastoma.
Zingerone (50, 100 mg/kg, p.o. daily for 21 days) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation in rat. Zingerone (10 mg/kg, i.p.) inhibits tumor progression through mitotic arrest, failure of cell division, and stimulation of apoptosis.
| Molecular Weight | 194.23 |
| Formula | C11H14O3 |
| CAS Number | 122-48-5 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Modje Kazemi, et al. Zingerone improves the immune responses in an animal model of breast cancer
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