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Zanubrutinib

Cat. No. M10025
Zanubrutinib Structure
Synonym:

BGB-3111

Size Price Availability Quantity
2mg USD 90  USD100 In stock
5mg USD 135  USD150 In stock
10mg USD 225  USD250 In stock
25mg USD 450  USD500 In stock
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Quality Control
Biological Activity

Zanubrutinib (BGB-3111) is a potent and highly selective small molecule inhibitor of Bruton's tyrosine kinase (BTK). Zanubrutinib (BGB-3111) selectively binds to and inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 471.55
Formula C27H29N5O3
CAS Number 1691249-45-2
Purity 100.0%
Solubility DMSO 90 mg/mL
Storage at -20°C
References

Efficacy of Zanubrutinib in the Treatment of Bing-Neel Syndrome
Jonathan Wong, et al. Hemasphere. 2018 Nov 30;2(6):e155. PMID: 31723793.

Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase
Yunhang Guo, et al. J Med Chem. 2019 Sep 12;62(17):7923-7940. PMID: 31381333.

Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL
Constantine S Tam, et al. Blood. 2019 Sep 12;134(11):851-859. PMID: 31340982.

Second-generation inhibitors of Bruton tyrosine kinase
Jingjing Wu, et al. J Hematol Oncol. 2016 Sep 2;9(1):80. PMID: 27590878.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Zanubrutinib, BGB-3111 supplier, BTK, inhibitors

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